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Author contributions: T. In this study, we uncover a G-protein—coupled receptor GPCR priming mechanism that results from the synergistic effects of two distinct G proteins. Although recent structural and spectroscopic studies of GPCR structure reveal a broad receptor conformational landscape, G-protein activation and downstream signaling are still viewed through the lens of individual ternary complexes between ligand, receptor, and individual effectors.

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Rain and snow showers this evening transitioning to snow showers overnight. Low 22F. Winds NW at 10 to 20 mph.